diff --git a/mite_data/data/MITE9999999.json b/mite_data/data/MITE9999999.json new file mode 100644 index 000000000..aaeb1d9b7 --- /dev/null +++ b/mite_data/data/MITE9999999.json @@ -0,0 +1,65 @@ +{ + "accession": "MITE9999999", + "status": "active", + "comment": "C\u2013N bond formation between W-W on the core peptide WHIW", + "changelog": [ + { + "version": "1", + "date": "2026-07-25", + "contributors": [ + "0009-0008-8086-5325" + ], + "reviewers": [ + "0009-0008-6482-7206" + ], + "comment": "New entry. Added missing Tailoring reaction terms and cofactor. Compresseded the reactions descriptions into 1 description to reduce redundancies. " + } + ], + "enzyme": { + "name": "ScaP", + "description": "Cytochrome P450", + "references": [ + "doi:10.1021/jacs.3c07416" + ], + "databaseIds": { + "uniprot": "UPI001160DEFE" + }, + "cofactors": { + "organic": [ + "Heme", + "NADP" + ], + "inorganic": [ + "Fe" + ] + } + }, + "reactions": [ + { + "tailoring": [ + "Biaryl bond formation", + "Cyclization", + "Oxidation" + ], + "description": "ScaP installs a C-N cross-link (Trp1-C to Trp4-N) on the motif WHIW of ScaA precursor peptide. The mature product Canumycin, is trimethylated at the free N-terminus of the Trp1 residue by the N-methyltransferase. 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